Cobra Venom Factor
A600
ApplicationsOther Application
Product group Proteins / Signaling Molecules
Overview
- SupplierQuidelOrtho
- Product NameCobra Venom Factor
- Delivery Days Customer7
- ApplicationsOther Application
- CertificationResearch Use Only
- Scientific DescriptionCobra Venom Factor (CVF), sometimes referred to as C3b (Cobra), is the non-toxic, complement-activating component of cobra venom. Like naturally occurring human C3b, CVF forms a complex, or convertase, with complement components Factor B and Factor D. This CVFBbD convertase is capable of activating C3 in a wide variety of species via the alternative complement pathway. CVFBbD convertase is Factor H resistant and is therefore not blocked through the activity of Factor I or CR1 and can convert nearly 100% of the C3 to C3 and C5 fragments. Levels of iC3b, C3a, SC5b-9, C5a and the Factor B cleavage product Bb are all extremely high in CVF treated sera. This product has been used in an experimental setting to deplete complement activity in vitro and in vivo. For more information contact Quidel Technical Support.
- UNSPSC12352202