Cochliodone A

MedChem Express

Cochliodone A [1072931-48-6]

14

1072931-48-6

Research Use Only

C34H38O12

638.66

Cochliodone A is an active compound extracted from cultures of the deep-sea derived fungus Chaetomium sp. and has antibacterial and anticancer activity. Cochliodone A is toxic to a variety of bacteria, with MICs of 15.3 microg/mL (V. vulnificus), 32.7 microg/mL (V. rotiferianus), 15.9 microg/mL (S. aureus ATCC 43300), and 16.3 microg/mL (S . aureus CGMCC 1.12409). Cochliodone A also inhibits a variety of cancer cell lines, with IC50s of 28.1 microM (A549), 20.7 microM (HeLa), and 23.2 microM (Hep G2)[1].

O=C(C1=CO[C@@]2(CCC[C@@H](C)O2)CC1=C3C(C([C@@](OC(C)=O)(C)C4=O)=O)=C5C4=CO[C@]6(O[C@H](C)CCC6)C5)[C@](C)(OC(C)=O)C3=O

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