Colcemid [477-30-5]

AdipoGen Life Sciences

Colcemid

10

477-30-5

Research Use Only

>98%

Danger,Excepted quantity

C21H25NO5

371.4

Anti-cancer compound [2, 6, 7, 10, 11, 14]. Cell synchronization agent. Used as a drug in chemotherapy by synchronizing tumor cells at metaphase, the radiosensitive stage of the cell cycle [11, 12, 14]. Microtubule assembly inhibitor. Depolymerizes microtubules and limits microtubule formation (inactivates spindle fibre formation) [1, 4, 5, 14]. Inhibits mitosis during cell division at metaphase by inhibiting spindle formation [2, 5, 7, 8, 14]. Low concentrations affect microtubule dynamics and cell migration, while high concentrations promote microtubule detachment from microtubule organizing center [14]. Apoptosis inducer [9, 13]. Thrombopoietic agent [3]. - Chemical. CAS: 477-30-5. Formula: C21H25NO5. MW: 371.4. Semisynthetic from colchicine (Prod. No. AG-CN2-0048). Anti-cancer compound. Cell synchronization agent. Used as a drug in chemotherapy by synchronizing tumor cells at metaphase, the radiosensitive stage of the cell cycle. Microtubule assembly inhibitor. Depolymerizes microtubules and limits microtubule formation (inactivates spindle fibre formation). Inhibits mitosis during cell division at metaphase by inhibiting spindle formation. Low concentrations affect microtubule dynamics and cell migration, while high concentrations promote microtubule detachment from microtubule organizing center. Apoptosis inducer. Thrombopoietic agent.

CNC1CCC2=C(C(OC)=C(OC)C(OC)=C2)C2=CC=C(OC)C(=O)C=C12

-20°C,2°C to 8°C

UN 2811

12352200