Colchicine

MedChem Express

Colchicine [64-86-8]

10

64-86-8

Research Use Only

99.98

C22H25NO6

399.44

Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC 50 of 3 nM. Colchicine is also a competitive antagonist of the alpha3 glycine receptors (GlyRs) . Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research [1] [2] [3] [4] [5] .

CC(N[C@H](C1=C2)CCC3=CC(OC)=C(OC)C(OC)=C3C1=CC=C(OC)C2=O)=O

-20°C,2°C to 8°C

12352200