Collagen I antibody [COL-1]

GeneTex

Collagen I antibody [COL-1]

9

The antibody is reactive with the native (helical) form of collagen type I in ELISA and dot blot. The product is not reactive when tested on thermally denatured molecules. In immunohistochemical staining of acetone-fixed and unfixed frozen sections, a str

IHC-Fr: 1:2000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Dot Blot, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

COL-1

Unconjugated

COL1A1

collagen type I alpha 1 chain

alpha-1 type I collagen; collagen alpha-1(I) chain; collagen, type I, alpha 1

Mouse

IgG1

Collagen alpha-1(I) chain

Collagens are highly conserved throughout evolution and are characterised by an uninterrupted Glycine X Y triplet repeat that is a necessary part of the triple helical structure. Type I collagen (95 kDa) is found in bone, cornea, skin and tendon. Mutations in the encoding gene are associated with osteogenesis imperfecta, Ehlers Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for Platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor.

Bovine, Deer, Human, Mouse, Porcine, Rabbit, Rat

-20°C or -80°C,2°C to 8°C

12352203