Collagen V antibody [MC5-HA]

GeneTex

Collagen V antibody [MC5-HA]

9

GTX19812 reacts with native human as well as heat denatured human collagen type V in RIA, ELISA and immunoblot/WB assays. Does not react with other collagen types I, II, III, and IV. Human plasma proteins do not interfere with binding to collagen.

ELISA: 1/1000. IHC-Fr: 1/20 if FITC-labeled secondary antibodies are used. Otherwise use at an assay dependent dilution. RIA: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Predicted molecular weight: ~180 kDa. Is unsuitable for IHC-P. Optimal dilutions/concentrations should be determined by the end user.

Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, RadioImmunoAssay

Research Use Only

Monoclonal

MC5-HA

0.2 mg/ml

Unconjugated

COL5A1

collagen type V alpha 1 chain

collagen alpha-1(V) chain; collagen, type V, alpha 1; EDSC; EDSCL1; FMDMF

Mouse

IgM

Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Collagen V is composed of several subunits as follows: trimers of two alpha 1(V) and one alpha 2(V) chains in most tissues and trimers of one alpha 1(V), one alpha 2(V), and one alpha 3(V) chains in placenta. Type V Collagen is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue specific chain combinations. Mutations in this gene are associated with Ehlers Danlos syndrome, types I and II.

Human

2°C to 8°C

12352203