ConA Lectin

GeneTex

ConA Lectin

9

Labeling/Conjugation, Purification/Extraction/Isolation

Research Use Only

10 mg/ml

Unconjugated

Concanavalin A is a lectin protein (MW 104kDa), homotetramer 26 kDa; originally extracted from the jack-bean, Canavalia ensiformis. It binds specifically to certain structures found in various sugars alpha-mannosyl and alpha-glucosyl residues in glycoproteins. It was the first lectin to be available on a commercial basis and is widely used in biology and biochemistry to characterize glycoproteins and other sugar-containing entities. It is also used to purify macromolecules in lectin affinity chromatography. Concanavalin A interacts with diverse receptors containing mannose carbohydrates (serum and membrane glycoproteins).ConA agglutinate strongly erythrocytes without being blood group specific. Normal cell re agglutinated after trypsinisation. ConA is a also a lymphocyte mitogen.ConA reacts with many bacteria, like E. coli Dictyostelium discoideum et B. substilis It is also widely believed to be involved in the interaction between alpha-mannosyl oligosaccharides on the surface of the HIV virus and the human T cell lymphocyte. Inhibiting/Eluting sugars: 200 alpha-mM alpha-methyl mannoside / 200 mM alpha-methyl glucoside mixture. Carbohydrate-Binding Specificity of Con A: (Manalpha1,2Manalpha1,2Man > Manalpha1,2Man > alpha-Man > alpha-Glc > alphaGlcNAc

2°C to 8°C

12352202