Concanamycin B [81552-33-2]

TargetMol Chemicals

Concanamycin B [81552-33-2]

999

81552-33-2

Chemical

Research Use Only

Concanamycin B

C45H73NO14

852.072

Concanamycin B is a macrolide antibiotic that selectively inhibits vacuolar type H+-ATPases (IC50 = 5 nM), thereby blocking vacuolar organelle acidification and early to late endosomal transport. It interferes with bone resorption, maturation of CD8 T lymphocytes, and prevents processing of major histocompatibility complex (MHC) class II precursors in human B cells, inhibiting MHC class II molecule expression on the cell surface.

3 years

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-20°C

12352200