Western blot All lanes: COPS4 antibody at 8ug/ml Lane 1: Hela whole cell lysate Lane 2: HepG2 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 47, 41 kDa Observed band size: 47 kDa
COPS4 Antibody
CSB-PA880098ESR2HU
ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetCOPS4
Overview
- SupplierCusabio
- Product NameCOPS4 Antibody
- Delivery Days Customer20
- ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID51138
- Target nameCOPS4
- Target descriptionCOP9 signalosome subunit 4
- Target synonymsCOP9 constitutive photomorphogenic homolog subunit 4; COP9 constitutive photomorphogenic-like protein subunit 4; COP9 signalosome complex subunit 4; CSN4; JAB1-containing signalosome subunit 4; SGN4; signalosome subunit 4; testis tissue sperm-binding protein Li 42a
- HostRabbit
- IsotypeIgG
- Protein IDQ9BT78
- Protein NameCOP9 signalosome complex subunit 4
- Scientific DescriptionComponent of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203