IHC image of CSB-PA860346LA01HU diluted at 1:300 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system.
IHC image of CSB-PA860346LA01HU diluted at 1:300 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system.
COPS8 Antibody
CSB-PA860346LA01HU
ApplicationsELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetCOPS8
Overview
- SupplierCusabio
- Product NameCOPS8 Antibody
- Delivery Days Customer20
- ApplicationsELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID10920
- Target nameCOPS8
- Target descriptionCOP9 signalosome subunit 8
- Target synonymsCOP9; COP9 constitutive photomorphogenic homolog subunit 8; COP9 homolog; COP9 signalosome complex subunit 8; CSN8; hCOP9; JAB1-containing signalosome subunit 8; SGN8; signalosome subunit 8
- HostRabbit
- IsotypeIgG
- Protein IDQ99627
- Protein NameCOP9 signalosome complex subunit 8
- Scientific DescriptionComponent of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203