PLpro (SARS Coronavirus) (rec.) (His)

Catalog number: SBB-DE0024-C050
Brand: South Bay Bio
Packing: 50 ug
Price: € 233.00
Expected delivery time: 7 days
Quantity:

Product specifications for - PLpro (SARS Coronavirus) (rec.) (His)

Overview: 
Product group: Corona Related Products
Category: Proteins
Species: Human
Target: orf1ab
Target description: orf1a polyprotein (pp1a);orf1ab polyprotein (pp1ab)
Properties: 
Purity: >95% (SDS-PAGE)
Molecular weight: ~37kDa
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352202
Form supplied: Liquid. In 50mM HEPES pH 7.5, 100mM sodium chloride, 1mM TCEP.
Storage instructions: -80-¦C
Scientific information: 
Scientific info: Protein. PLpro (Papain-like Protease) (aa 1540-1841)is fused at the N-terminus to a His-tag. Source: E. coli. Formulation: Liquid. In 50mM HEPES pH 7.5, 100mM sodium chloride, 1mM TCEP. Purity: >95% (SDS-PAGE). The severe acute respiratory syndrome coronavirus papain-like protease (SARS-CoV PLpro) is involved in the processing of the viral polyprotein. Proteolytic processing of the coronavirus replicase poly-protein is essential for generating a functional virus replication complex. PLpro possesses both deubiquitinating or deISGylating activity and can process Lys48 and Lys63 linked polyubiquitin chains (free chains or from cellular substrates). It works in concert together with nsp4 in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication. It strongly antagonizes the innate immune induction of type I interferon by blocking the phosphorylation, dimerization and therefore the nuclear translocation of host IRF3. In addition, it prevents also host NF-kappa-B signaling. - The severe acute respiratory syndrome coronavirus papain-like protease (SARS-CoV PLpro) is involved in the processing of the viral polyprotein. Proteolytic processing of the coronavirus replicase poly-protein is essential for generating a functional virus replication complex. PLpro possesses both deubiquitinating or deISGylating activity and can process Lys48 and Lys63 linked polyubiquitin chains (free chains or from cellular substrates). It works in concert together with nsp4 in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication. It strongly antagonizes the innate immune induction of type I interferon by blocking the phosphorylation, dimerization and therefore the nuclear translocation of host IRF3. In addition, it prevents also host NF-kappa-B signaling.
Gene ID: 1489680
Swiss prot ID: P0C6U8
Safety information: 
Hazard information: Non-hazardous
Additional information: 
Synonyms: SBB-DE0024-C050; South Bay Bio; ORF1a polyprotein; orf1a polyprotein (pp1a);orf1ab polyprotein (pp1ab); sars1