Cotinine

MedChem Express

Cotinine [486-56-6]

5

486-56-6

Research Use Only

99.56

C10H12N2O

176.219

Cotinine ((-)-Cotinine) is an orally active alkaloid found in tobacco and is the primary metabolite of nicotine. Cotinine is metabolized by CYP2A13 into trans-3-hydroxycotinine. Cotinine is used as a biomarker to measure exposure to tobacco smoke components. Cotinine has vasodepressor activity. The mixture of cotinine and nicotine (Nicotine) has antiproliferative activity against pterygium. (S)-(-)-Cotinine activates nicotinic acetylcholine receptors ( nAChR ) in a calcium-dependent manner, leading to the release of dopamine (Dopamine, HY-B0451). Cotinine ((-)-Cotinine) is used in research related to cardiovascular and inflammatory diseases [1] [2] [3] [4] [5] .

O=C1N(C)[C@H](C2=CC=CN=C2)CC1

2°C to 8°C

12352200