COX-2-IN-30 [1160498-08-7]

MedChem Express

COX-2-IN-30 [1160498-08-7]

10

1160498-08-7

Research Use Only

C17H16N6O3S

384.41

COX-2-IN-30 is a benzenesulfonamide derivative, as well as an orally active and dual inhibitor of COX (IC50=49 nM for COX-2, 10.4 microM for COX-1) and 5-LOX (IC50=2.4 microM). COX-2-IN-30 also inhibits transmembrane hCA IX and hCA XII isoform with nanomolar calss Ki values. COX-2-IN-30 exhibits analgesic, anti-inflammatory, and ulcerogenic activities, and does not show acute gastric effect[1].

O=C(C1=C(N(N=C1)C2=CC=C(C=C2)S(N)(=O)=O)N)N/N=C/C3=CC=CC=C3

12131703