COX-2/15-LOX-IN-7 [1860810-23-6]

MedChem Express

COX-2/15-LOX-IN-7 [1860810-23-6]

102

Research Use Only

C22H17F3N2

366.38

COX-2/15-LOX-IN-7 is a potent, selective and orally active dual inhibitor of COX-2 and 15-LOX with IC50 values of 0.022 and 1.19 microM. COX-2/15-LOX-IN-7 also inhibits COX-1 with an IC50 value of 28.081microM. COX-2/15-LOX-IN-7 has low cytotoxicity against human colorectal cancer HT-29 and HCT116 cell lines (IC50 >100 microM for both). COX-2/15-LOX-IN-7 exhibits non-ulcerogenic performance. COX-2/15-LOX-IN-7 can be used for the research of cancer[1].

FC(F)(F)C(C=C1)=CC=C1C(CC(C2=CC=CC=C2)=N3)N3C4=CC=CC=C4

12352200