COX-2/5-LOX-IN-4 [443919-96-8]

MedChem Express

COX-2/5-LOX-IN-4 [443919-96-8]

5

443919-96-8

Research Use Only

C29H29FN2O5S

536.61

COX-2/5-LOX-IN-4 (Compound 1) is a dual inhibitor that acts on both COX-2 and 5-LOX, with IC50 values of 0.05 microM for COX-2 and 0.003 microM for 5-LOX. By inhibiting the arachidonic acid metabolism pathway, COX-2/5-LOX-IN-4 reduces the production of prostaglandins and leukotrienes, alleviating inflammatory responses. In a rat ear edema model, intravenous administration (0.01 and 0.1 mg/kg) reduced edema by 41% and 44%, respectively, demonstrating significant anti-inflammatory effects. COX-2/5-LOX-IN-4 shows promise for studying the mechanisms of inflammatory diseases[1].

O=S(C1=CC=C(N2N=C(COC3=CC(F)=CC(C4(CCOCC4)OC)=C3)C=C2C5=CC=CC=C5)C=C1)(C)=O

12352200