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CP-100356 (hydrochloride)

HY-108347
MedChem Express
CAS Number142715-48-8
DownloadMSDS
Product group Chemicals
Estimated Purity99.68
Molecular Weight597.10
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Overview

  • Supplier
    MedChem Express
  • Product Name
    CP-100356 (hydrochloride) [142715-48-8]
  • Delivery Days Customer
    10
  • CAS Number
    142715-48-8
  • Certification
    Research Use Only
  • Estimated Purity
    99.68
  • Molecular Formula
    C31H37ClN4O6
  • Molecular Weight
    597.10
  • Scientific Description
    CP-100356 hydrochloride is an orally active dual MDR1 (P-gp)/BCRP inhibitor, with an IC50s of 0.5 and 1.5 microM for inhibiting MDR1-mediated Calcein-AM transport and BCRP-mediated Prazosin transport, respectively. CP-100356 hydrochloride is also a weak inhibitor of OATP1B1 (IC50=~66 microM). CP-100356 hydrochloride is devoid of inhibition against MRP2 and major human P450 enzymes (IC50>15 microM)[1].
  • SMILES
    [H]Cl.COC1=CC2=NC(NCCC3=CC=C(OC)C(OC)=C3)=NC(N4CC5=C(C=C(OC)C(OC)=C5)CC4)=C2C=C1OC
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200

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