CP-100356 (hydrochloride)

MedChem Express

CP-100356 (hydrochloride) [142715-48-8]

10

142715-48-8

Research Use Only

99.68

C31H37ClN4O6

597.10

CP-100356 hydrochloride is an orally active dual MDR1 (P-gp)/BCRP inhibitor, with an IC 50 s of 0.5 and 1.5 microM for inhibiting MDR1-mediated Calcein-AM transport and BCRP-mediated Prazosin transport, respectively. CP-100356 hydrochloride is also a weak inhibitor of OATP1B1 ( IC 50 =~66 microM). CP-100356 hydrochloride is devoid of inhibition against MRP2 and major human P450 enzymes (IC 50 >15 microM) [1] .

[H]Cl.COC1=CC2=NC(NCCC3=CC=C(OC)C(OC)=C3)=NC(N4CC5=C(C=C(OC)C(OC)=C5)CC4)=C2C=C1OC

2°C to 8°C

12352200