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CP-99994 (hydrochloride) [145148-39-6]

HY-12145
MedChem Express
CAS Number145148-39-6
Product group Chemicals
Molecular Weight369.33
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Overview

  • Supplier
    MedChem Express
  • Product Name
    CP-99994 (hydrochloride) [145148-39-6]
  • Delivery Days Customer
    9
  • CAS Number
    145148-39-6
  • Certification
    Research Use Only
  • Molecular Formula
    C19H26Cl2N2O
  • Molecular Weight
    369.33
  • Scientific Description
    CP-99994 hydrochloride is a Tachykinin neurokinin 1 (NK-1) receptor antagonist with a Ki of 0.25 nM. CP-99994 hydrochloride prevents colorectal sensitization in the context of visceral hypersensitivity. CP-99994 hydrochloride reduces colorectal hypersensitivity induced by acetic acid injections in a model of bladder-colon cross-sensitization. CP-99994 hydrochloride attenuates the neuroglial interactions and MAPK-p38 phosphorylation associated with visceral hypersensitivity[1].
  • SMILES
    COC(C=CC=C1)=C1CN[C@@H]2[C@H](C3=CC=CC=C3)NCCC2.Cl.Cl
  • UNSPSC
    12352200