CPUL1 [2043660-80-4]

MedChem Express

CPUL1 [2043660-80-4]

10

2043660-80-4

Research Use Only

C22H13Cl2N5O

434.28

CPUL1 is a TrxR inhibitor, which shows proliferation-inhibitory and anti-metastatic activity against A549 cells. CPUL1 influences EMT (epithelial-mesenchymal transition) via inducing ROS-mediated ERK/JNK signaling by inhibiting TrxR1 enzyme activity. CPUL1 in combination with alpha-Lipoic Acid (HY-N0492) or Dithiodipropionic acid (HY-W014395) is more effective[1].

N#CC1=C(OC2=C(C1C3=CC(Cl)=C(Cl)C=C3)C4=NC5=CC=CC=C5N=C4C=C2N)N

12131703