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Crenigacestat [1421438-81-4]

Crenigacestat [1421438-81-4]

T3633
TargetMol Chemicals
CAS Number1421438-81-4
DownloadMSDS
Product group Chemicals
Estimated Purity98.76%
Molecular Weight464.44
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    Crenigacestat [1421438-81-4]
  • Delivery Days Customer
    4
  • CAS Number
    1421438-81-4
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    Crenigacestat
  • Estimated Purity
    98.76%
  • Molecular Formula
    C22H23F3N4O4
  • Molecular Weight
    464.44
  • Scientific Description
    Crenigacestat (LY3039478) is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most tumor cell lines tested. It effectively inhibits mutant Notch receptor activity and, in a xenograft tumor model, inhibits the expression of Notch-regulated genes and N1ICD cleavage in the tumor microenvironment.
  • Shelf life instruction
    3 years
  • SMILES
    C[C@H](NC(=O)CCC(F)(F)F)C(=O)N[C@H]1c2ccccc2-c2cccnc2N(CCO)C1=O
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

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