cRIPGBM chloride [2361988-77-2]

TargetMol Chemicals

cRIPGBM chloride [2361988-77-2]

14

Chemical

Research Use Only

cRIPGBM chloride

C26H20ClFN2O2

446.9

cRIPGBM chloride is an orally active, proapoptotic compound derived from glioblastoma multiforme (GBM) cancer stem cells (CSCs). It specifically targets receptor-interacting protein kinase 2 (RIPK2) to trigger caspase 1-dependent apoptosis. By inhibiting the formation of the RIPK2/TAK1 prosurvival complex and promoting the assembly of the RIPK2/caspase 1 proapoptotic complex, cRIPGBM chloride efficiently suppresses tumor growth. This action results in significant anti-tumor activity in animal models in vivo.

3 years

[Cl-].O=C1C=2C=CC=CC2C(=O)C3=C1N(C(=[N+]3CC4=CC=C(F)C=C4)C)CC=5C=CC=CC5

-20°C

12352200