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Crizotinib (hydrochloride)

HY-50878A
MedChem Express
CAS Number1415560-69-8
DownloadMSDS
Product group Chemicals
Estimated Purity99.86
Molecular Weight486.80
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Crizotinib (hydrochloride) [1415560-69-8]
  • Delivery Days Customer
    10
  • CAS Number
    1415560-69-8
  • Certification
    Research Use Only
  • Estimated Purity
    99.86
  • Molecular Formula
    C21H23Cl3FN5O
  • Molecular Weight
    486.80
  • Scientific Description
    Crizotinib hydrochloride (PF-02341066 hydrochloride) is an orally bioavailable, selective, and ATP-competitive dual ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib hydrochloride (PF-02341066 hydrochloride) inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. It is also a ROS proto-oncogene 1 (ROS1) inhibitor. Crizotinib hydrochloride (PF-02341066 hydrochloride) has effective tumor growth inhibition[1][2][3].
  • SMILES
    ClC1=C(F)C=CC(Cl)=C1[C@H](OC2=CC(C3=CN(N=C3)C4CCNCC4)=CN=C2N)C.Cl
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200

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