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ProductsBack/CrkL antibody

CrkL antibody

GTX107677
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse
TargetCRKL
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Overview

  • Supplier
    GeneTex
  • Product Name
    CrkL antibody
  • Delivery Days Customer
    9
  • Antibody Specificity
    IP/MS validation was supported by references (PMID:30377387)
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.33 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID1399
  • Target name
    CRKL
  • Target description
    CRK like proto-oncogene, adaptor protein
  • Target synonyms
    crk-like protein; v-crk avian sarcoma virus CT10 oncogene homolog-like
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP46109
  • Protein Name
    Crk-like protein
  • Scientific Description
    This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • miR-124-3p Suppresses the Invasiveness and Metastasis of Hepatocarcinoma Cells via Targeting CRKL. Majid A et al., 2020, Front Mol Biosci
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  • miR-429-CRKL axis regulates clear cell renal cell carcinoma malignant progression through SOS1/MEK/ERK/MMP2/MMP9 pathway. Wang J et al., 2020 Jul, Biomed Pharmacother
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  • A high-throughput pipeline for validation of antibodies. Sikorski K et al., 2018 Nov, Nat Methods
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  • CRKL oncogene is downregulated by p53 through miR-200s. Tamura M et al., 2015 Aug, Cancer Sci
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