CrkL antibody
GTX107677
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetCRKL
Overview
- SupplierGeneTex
- Product NameCrkL antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.33 mg/ml
- ConjugateUnconjugated
- Gene ID1399
- Target nameCRKL
- Target descriptionCRK like proto-oncogene, adaptor protein
- Target synonymscrk-like protein; v-crk avian sarcoma virus CT10 oncogene homolog-like
- HostRabbit
- IsotypeIgG
- Protein IDP46109
- Protein NameCrk-like protein
- Scientific DescriptionThis gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- miR-124-3p Suppresses the Invasiveness and Metastasis of Hepatocarcinoma Cells via Targeting CRKL. Majid A et al., 2020, Front Mol BiosciRead more
- miR-429-CRKL axis regulates clear cell renal cell carcinoma malignant progression through SOS1/MEK/ERK/MMP2/MMP9 pathway. Wang J et al., 2020 Jul, Biomed PharmacotherRead more
- A high-throughput pipeline for validation of antibodies. Sikorski K et al., 2018 Nov, Nat MethodsRead more
- CRKL oncogene is downregulated by p53 through miR-200s. Tamura M et al., 2015 Aug, Cancer SciRead more
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![ELISA analysis of antigen using GTX60462 CrkL antibody [5E12]. Red : Control antigen 100ng Purple : Antigen 10ng Green : Antigen 50ng Blue : Antigen 100ng](https://www.genetex.com/upload/website/prouct_img/normal/GTX60462/GTX60462_20170912_ELISA_w_23061123_563.webp)
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