CrkL antibody

Name: CrkL antibody
SKU: GTX107677_G10
Availability: BackOrder

GTX107677

ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

TargetCRKL

Overview

Supplier
GeneTex
Product Name
CrkL antibody
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Concentration
0.33 mg/ml
Conjugate
Unconjugated
Gene ID1399
Target name
CRKL
Target description
CRK like proto-oncogene, adaptor protein
Target synonyms
crk-like protein, v-crk avian sarcoma virus CT10 oncogene homolog-like
Host
Rabbit
Isotype
IgG
Protein IDP46109
Protein Name
Crk-like protein
Scientific Description
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Majid A, Wang J, Nawaz M, et al. miR-124-3p Suppresses the Invasiveness and Metastasis of Hepatocarcinoma Cells via Targeting CRKL. Front Mol Biosci. 2020,7:223. doi: 10.3389/fmolb.2020.00223
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Wang J, Wang C, Li Q, et al. miR-429-CRKL axis regulates clear cell renal cell carcinoma malignant progression through SOS1/MEK/ERK/MMP2/MMP9 pathway. Biomed Pharmacother. 2020,127:110215. doi: 10.1016/j.biopha.2020.110215
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Sikorski K, Mehta A, Inngjerdingen M, et al. A high-throughput pipeline for validation of antibodies. Nat Methods. 2018,15(11):909-912. doi: 10.1038/s41592-018-0179-8
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Tamura M, Sasaki Y, Kobashi K, et al. CRKL oncogene is downregulated by p53 through miR-200s. Cancer Sci. 2015,106(8):1033-40. doi: 10.1111/cas.12713
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