CRT0066101 (dihydrochloride)

MedChem Express

CRT0066101 (dihydrochloride) [1883545-60-5]

10

1883545-60-5

Research Use Only

99.92

C18H24Cl2N6O

411.33

CRT0066101 dihydrochloride is a potent and orally active PKD inhibitor with IC 50 values of 1 nM, 2.5 nM and 2 nM for PKD1 , PKD2 , and PKD3 , respectively [1] . CRT0066101 dihydrochloride is also a potent PIM2 inhibitor with an IC 50 of ~135.7 nM. CRT0066101 dihydrochloride exhibits anti-inflammatory activity in mice LPS (HY-D1056)-induced lung injury models, and has anticancer effects [1] [2] [3] .

OC1=CC=C(C2=CN(C)N=C2)C=C1C3=NC=CC(NC[C@H](N)CC)=N3.[H]Cl.[H]Cl

2°C to 8°C

12352200