CRT0066101

MedChem Express

CRT0066101

5

Research Use Only

99.66

C18H22N6O

338.41

CRT0066101 is a potent and orally active PKD inhibitor with IC 50 values of 1 nM, 2.5 nM and 2 nM for PKD1 , PKD2 , and PKD3 , respectively [1] . CRT0066101 is also a potent PIM2 inhibitor with an IC 50 of ~135.7 nM. CRT0066101 exhibits anti-inflammatory activity in mice LPS (HY-D1056)-induced lung injury models, and has anticancer effects [1] [2] [3] .

N[C@H](CC)CNC1=NC(C2=C(O)C=CC(C3=CN(C)N=C3)=C2)=NC=C1

-20°C,2°C to 8°C

12352200