CRT0066101 (trihydrochloride)

MedChem Express

CRT0066101 (trihydrochloride) [1781742-22-0]

5

1781742-22-0

Research Use Only

C18H25Cl3N6O

447.79

CRT0066101 trihydrochloride is the trihydrochloride salt form of CRT0066101 (HY-15698). CRT0066101 trihydrochloride is an orally active PKD inhibitor with IC 50 values of 1 nM, 2.5 nM and 2 nM for PKD1 , PKD2 , and PKD3 , respectively. CRT0066101 trihydrochloride is also an inhibitor for PIM2 with an IC 50 of ~135.7 nM. CRT0066101 trihydrochloride exhibits anti-inflammatory activity in mice LPS (HY-D1056)-induced lung injury models, and has anticancer effects [1] [2] [3] .

[H]Cl.[H]Cl.[H]Cl.N[C@H](CC)CNC1=NC(C2=C(O)C=CC(C3=CN(C)N=C3)=C2)=NC=C1

12352200