CU-3

MedChem Express

CU-3

10

Research Use Only

C16H12N2O4S3

392.47

CU-3 is the racemate of (5Z,2E)-CU-3. (5Z,2E)-CU-3 is a potent and selective inhibitor against the alpha-isozyme of DGK with an IC50 value of 0.6 microM, competitively inhibits the affinity of DGKalpha for ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKalpha. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells[1].

O=C1N(C(S/C1=C\C=C\C2=CC=CO2)=S)NS(=O)(C3=CC=CC=C3)=O

12352200