CU-T12-9

MedChem Express

CU-T12-9 [1821387-73-8]

10

1821387-73-8

Research Use Only

99.96

C17H13F3N4O2

362.31

CU-T12-9 is a specific TLR1/2 agonist with EC 50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay. CU-T12-9 activates both the innate and the adaptive immune systems. CU-T12-9 selectively activates the TLR1/2 heterodimer, not TLR2/6. CU-T12-9 signals through NF-kappaB and invokes an elevation of the downstream effectors TNF-alpha, IL-10, and iNOS [1] .

CNC1=CC=C(C=C1N2C=C(N=C2)C3=CC=C(C=C3)C(F)(F)F)[N+]([O-])=O

-20°C,2°C to 8°C

12352200