Curcumin (high purity) Lipodisq(tm) Sterile Solution

Innaxon

Curcumin (high purity) Lipodisq Sterile Solution [458-37-7]

10

Research Use Only

1 mg/ml

Liquid

Chemical. CAS: 458-37-7. Formula: C21H20O6. MW: 368.4. Curcumin (high purity) Lipodisq Sterile Solution is a ready-to-use nano-formulated aqueous solution. Curcumin is a yellow pigment present in the spice turmeric (Curcuma longa) that has been associated with anti-oxidant, anti-inflammatory, anti-cancer, anti-viral and anti-bacterial activities [1-20]. However, curcumin shows poor absorption, biodistribution, metabolism and bioavailability. To increase the bioavailability, enhance circulation, improve permeability and resistance to metabolic processing several formulations of curcumin have been prepared which include nanoparticles, liposomes, micelles and phospholipid complexes [21-25]. Curcumin (high purity) Lipodisq is based on a nanoparticle (11-40nm) drug delivery system comprising a discoidal phospholipid bilayer membrane stabilized by a chaperone molecule annulus. Internal properties of the phospholipid membrane support the disposition and stabilization of drug molecule candidates and preserve the native conformation of membrane molecules. The resulting encapsulated actives are rendered water-soluble and specialized for intra-cellular penetration/delivery via endosomal uptake mechanisms. Lipodisq solutions show a good safety profile and are suitable for in vitro and in vivo investigations. - Curcumin (high purity) Lipodisq Sterile Solution is a ready-to-use nano-formulated aqueous solution. Curcumin is a yellow pigment present in the spice turmeric (Curcuma longa) that has been associated with anti-oxidant, anti-inflammatory, anti-cancer, anti-viral and anti-bacterial activities [1-20]. However, curcumin shows poor absorption, biodistribution, metabolism and bioavailability. To increase the bioavailability, enhance circulation, improve permeability and resistance to metabolic processing several formulations of curcumin have been prepared which include nanoparticles, liposomes, micelles and phospholipid complexes [21-25]. Curcumin (high purity) Lipodisq is based on a nanoparticle (11-40nm) drug delivery system comprising a discoidal phospholipid bilayer membrane stabilized by a chaperone molecule annulus. Internal properties of the phospholipid membrane support the disposition and stabilization of drug molecule candidates and preserve the native conformation of membrane molecules. The resulting encapsulated actives are rendered water-soluble and specialized for intra-cellular penetration/delivery via endosomal uptake mechanisms. Lipodisq solutions show a good safety profile and are suitable for in vitro and in vivo investigations.

2°C to 8°C

41116133