anti-ATRX antibody [ATRX-2/39f/B8]
ARG10526
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman
TargetATRX
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-ATRX antibody [ATRX-2/39f/B8]
- Delivery Days Customer23
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDATRX-2/39f/B8
- ConjugateUnconjugated
- Gene ID546
- Target nameATRX
- Target descriptionATRX chromatin remodeler
- Target synonymsalpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae); ATP-dependent helicase ATRX; JMS; MRX52; RAD54; RAD54L; transcriptional regulator ATRX; XH2; X-linked helicase II; X-linked nuclear protein; XNP; ZNF-HX
- HostMouse
- IsotypeIgG1
- Scientific DescriptionThe protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Aug 2013]
- ReactivityHuman
- Storage Instruction-20°C
- UNSPSC12352203