anti-CD105 / Endoglin antibody [MEM-229] (Biotin)
ARG65492
ApplicationsFlow Cytometry
Product group Antibodies
ReactivityHuman
TargetENG
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-CD105 / Endoglin antibody [MEM-229] (Biotin)
- Delivery Days Customer23
- ApplicationsFlow Cytometry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDMEM-229
- Concentration1 mg/ml
- ConjugateBiotin
- Gene ID2022
- Target nameENG
- Target descriptionendoglin
- Target synonymsCD105 antigen; END; endoglin; HHT1; ORW1
- HostMouse
- IsotypeIgG2a
- Scientific DescriptionCD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.
- ReactivityHuman
- Storage Instruction2°C to 8°C
- UNSPSC12352203