anti-CD71 / Transferrin Receptor antibody [MEM-75] (Biotin)
ARG62920
ApplicationsFlow Cytometry
Product group Antibodies
ReactivityHuman
TargetTFRC
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-CD71 / Transferrin Receptor antibody [MEM-75] (Biotin)
- Delivery Days Customer23
- ApplicationsFlow Cytometry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDMEM-75
- Concentration1 mg/ml
- ConjugateBiotin
- Gene ID7037
- Target nameTFRC
- Target descriptiontransferrin receptor
- Target synonymsCD71; IMD46; p90; T9; TFR; TFR1; TR; transferrin receptor protein 1; TRFR
- HostMouse
- IsotypeIgG1
- Scientific DescriptionCD71 (transferrin receptor) is a type II transmembrane glycoprotein expressed as homodimer in erythroid blood cell line and in activated leukocytes. Upon binding of holotransferrin (complex of transferrin and iron ions), CD71 is internalized by clathrin-mediated endocytosis. Acidification of endosomes by vesicular membrane proton pumps leads to dissociation of iron ions, whereas transferrin (apotransferrin) remains associated with CD71 and recycles to the cell surface, where it is released upon exposure to normal pH. CD71 is also involved in uptake of non-transferrin bound iron.
- ReactivityHuman
- Storage Instruction2°C to 8°C
- UNSPSC12352203