anti-DHCR7 antibody
![Research Use Only](static/images/certificates/ruo.jpg)
ARG56151
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman
TargetDHCR7
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-DHCR7 antibody
- Delivery Days Customer23
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID1717
- Target nameDHCR7
- Target description7-dehydrocholesterol reductase
- Target synonyms7-dehydrocholesterol reductase; 7-DHC reductase; delta-7-dehydrocholesterol reductase; delta7-sterol reductase; putative sterol reductase SR-2; SLOS; sterol delta-7-reductase; sterol reductase SR-2
- HostRabbit
- IsotypeIgG
- Scientific DescriptionThis gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS); a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by mental retardation, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Aug 2009]
- ReactivityHuman
- Storage Instruction-20°C
- UNSPSC12352203