anti-ERBB2 / HER2 antibody
ARG54982
ApplicationsWestern Blot
Product group Antibodies
ReactivityMouse
TargetErbb2
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-ERBB2 / HER2 antibody
- Delivery Days Customer23
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID13866
- Target nameErbb2
- Target descriptionerb-b2 receptor tyrosine kinase 2
- Target synonymsavian erythroblastosis oncogene B 2; c-erbB; c-erbB2; c-erbB-2; c-ne; c-neu; ErbB-; Erbb-2; HER; HER-; HER2; HER-2; l11Ju; l11Jus8; mKIAA3023; Ne; Neu; Neu oncogene; p185erbB2; proto-oncogene c-ErbB-2; proto-oncogene NEU; receptor tyrosine-protein kinase erbB-2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
- HostRabbit
- IsotypeIgG
- Scientific DescriptionProtein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity).
- ReactivityMouse
- Storage Instruction-20°C
- UNSPSC12352203