GTX70115 IHC Image
BRCA1 antibody [6B4] - ChIP grade - KO/KD, Orthogonal Validated
GTX70115
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
Overview
- SupplierGeneTex
- Product NameBRCA1 antibody [6B4] - ChIP grade - KO/KD, Orthogonal Validated
- Delivery Days Customer10
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID6B4
- Concentration2.75 mg/ml
- HostMouse
- IsotypeIgG
- Scientific DescriptionThis gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009]
- ReactivityHuman
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Differential expressions of BRCA1 and BRCA2 in infantile gynecomastia. Bernard-Gallon DJ et al., 2004 Jan-Feb, Anticancer ResRead more
- Dual disruption of DNA repair and telomere maintenance for the treatment of head and neck cancer. Lajud SA et al., 2014 Dec 15, Clin Cancer ResRead more
- Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response. Li S et al., 2000 Jul 13, NatureRead more