BUB3 antibody, PAb
ORB76159
ApplicationsWestern Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
Product group Antibodies
ReactivityHamster, Human, Mouse, Rat
Overview
- SupplierBiorbyt
- Product NameBUB3 antibody, PAb
- Delivery Days Customer16
- ApplicationsWestern Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
- Applications SupplierWestern blot - 0.1-0.5 μg/ml - Human - Mouse, Rat - Immunohistochemistry(Paraffin-embedded Section) - 0.5-1 μg/ml - Human, Rat - Mouse - By Heat Immunohistochemistry(Frozen Section) - 0.5-1 μg/ml - Rat - Human, Mouse - Immunocytochemistry - 0.5-1 μg/ml -
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration500 ug/ml
- HostRabbit
- IsotypeIgG
- Scientific DescriptionRabbit Polyclonal to BUB3. BUB3(BUDDING UNINHIBITED BY BENZIMIDAZOLES 3) is a protein that in humans is encoded by the BUB3 gene. And it is mapped on 10q26.13.Bub3 is also a protein involved with the regulation of the Spindle Assembly Checkpoint (SAC); though BUB3 is non-essential in yeast, it is essential in higher eukaryotes. As one of the checkpoint proteins, Bub3 delays the irreversible onset of anaphase through direction of kinetochore localization during prometaphase to achieve biorentation. Bub3 directs the localization of Bub1 at the kinetochore in order to activate the SAC. Bub3 also acts as a regulator in that it affects binding of Mad3 to Mad2. Using deletion analysis, the authors identified a domain of BUB1 that is required both for binding BUB3 and for kinetochore localization of BUB1.
- ReactivityHamster, Human, Mouse, Rat
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203