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GTX76456 FACS Image
CD42b antibody [AK2] (Biotin)
![Research Use Only](static/images/certificates/ruo.jpg)
GTX76456
Overview
- SupplierGeneTex
- Product NameCD42b antibody [AK2] (Biotin)
- Delivery Days Customer10
- ApplicationsFlow Cytometry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDAK2
- Concentration0.1 mg/ml
- HostMouse
- IsotypeIgG
- Scientific DescriptionGlycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy. [provided by RefSeq, Oct 2013]
- ReactivityHuman
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Mucin AgC10 from Trypanosoma cruzi Interferes with L-selectin-mediated monocyte adhesion. Alcaide P et al., 2010 Mar, Infect ImmunRead more
- Novel ex vivo culture method for human monocytes uses shear flow to prevent total loss of transendothelial diapedesis function. Tsubota Y et al., 2014 Jan, J Leukoc BiolRead more