CLOCK antibody [C2C3], C-term detects CLOCK protein at cytoplasm and nucleus in mouse brain by immunohistochemical analysis. Sample: Paraffin-embedded mouse brain. CLOCK antibody [C2C3], C-term (GTX102318) diluted at 1:500. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min
CLOCK antibody [C2C3], C-term
GTX102318
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameCLOCK antibody [C2C3], C-term
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1.28 mg/ml
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203