GTX24837 ICC/IF Image
eIF2 alpha (phospho Ser52) antibody
GTX24837
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry
Product group Antibodies
ReactivityC. Elegans, Chicken, Drosophila, Feline, Human, Mouse, Primate, Rat, Yeast
Overview
- SupplierGeneTex
- Product NameeIF2 alpha (phospho Ser52) antibody
- Delivery Days Customer10
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- HostRabbit
- IsotypeIgG
- Modification TypePhosphorylated
- Scientific DescriptionThe translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010]
- ReactivityC. Elegans, Chicken, Drosophila, Feline, Human, Mouse, Primate, Rat, Yeast
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Cigarette smoke induces endoplasmic reticulum stress and the unfolded protein response in normal and malignant human lung cells. Jorgensen E et al., 2008 Aug 11, BMC CancerRead more