HNRNPD Antibody
CSB-PA02544A0RB
ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
Overview
- SupplierCusabio
- Product NameHNRNPD Antibody
- Delivery Days Customer20
- ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- HostRabbit
- IsotypeIgG
- Scientific DescriptionBinds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3\\\-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5\\\-UUAG-3\\\ sequence and also weaker to the single-stranded 5\\\-TTAGGG-3\\\ telomeric DNA repeat. Binds RNA oligonucleotides with 5\\\-UUAGGG-3\\\ repeats more tightly than the telomeric single-stranded DNA 5\\\-TTAGGG-3\\\ repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203