![HPK1-IN-22 HPK1-IN-22](https://www.targetmol.com/file/group1/M00/03/B5/CgoaDmTA-FiEHubfAAAAAPl1crE753.png)
HPK1-IN-22
T62927
Overview
- SupplierTargetMol Chemicals
- Product NameHPK1-IN-22
- Delivery Days Customer14
- CAS Number2380300-79-6
- Category SupplierChemical
- Chemical NameHPK1-IN-22
- Molecular FormulaC26H30N4O2S
- Molecular Weight462.61
- Scientific DescriptionHPK1-IN-22 (compound ZYF0033) is a haematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 of less than 10 nM for MBP protein-based phosphorylation inhibition. HPK1-IN-22 reduces phosphorylation of SLP76 (serine 376) and promotes anti-cancer immune responses. HPK1-IN-22 inhibits tumor growth and increases intra-tumor infiltration of DCs, NK cells and CD107a+CD8+ T cells, but decreases infiltration of T cells, PD-1+CD8+ T cells, TIM-3+CD8+ T cells and LAG3+CD8+ T cells in a 4T-1 homozygous mouse model.
- Shelf life instruction3 years
- SMILESO(CC1=CC(C#CC(C)(C)O)=CC=C1)C2=CC(C=3SC(=NC3)C4CCN(C)CC4)=CN=C2N
- Storage Instruction-20°
- UNSPSC12352200