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GTX01223-pro Image
Human Urokinase protein, His tag
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GTX01223-PRO020
Product group Molecular Biology
Overview
- SupplierGeneTex
- Product NameHuman Urokinase protein, His tag
- Delivery Days Customer9
- CertificationResearch Use Only
- Scientific DescriptionThis gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimers disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
- Storage Instruction-20°C
- UNSPSC41116133