Midostaurin [120685-11-2]
HY-10230
Overview
- SupplierMedChem Express
- Product NameMidostaurin [120685-11-2]
- Delivery Days Customer10
- CAS Number120685-11-2
- CertificationResearch Use Only
- Molecular FormulaC35H30N4O4
- Molecular Weight570.64
- Scientific DescriptionMidostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCalpha/beta/gamma, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRbeta and VEGFR1/2 with IC50s ranging from 22-500 nM. Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects.
- SMILESO=C(C1=CC=CC=C1)N(C)[C@H]2[C@@H](OC)[C@@]3(C)N(C4=C5C=CC=C4)C6=C5C7=C(C(NC7)=O)C8=C6N(C9=CC=CC=C98)[C@@](O3)([H])C2
- Storage Instruction-20°C,-80°C
- UNSPSC12352200