PAN2 Antibody, Biotin conjugated
CSB-PA681391LD01HU
ApplicationsELISA
Product group Antibodies
ReactivityHuman
Overview
- SupplierCusabio
- Product NamePAN2 Antibody, Biotin conjugated
- Delivery Days Customer20
- ApplicationsELISA
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateBiotin
- HostRabbit
- IsotypeIgG
- Scientific DescriptionCatalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3\\\-5\\\ exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5\\\-3\\\ exonucleolytic degradation by XRN1.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203