PDCD4 (phospho Ser457) antibody [2E10.C12]
![Research Use Only](static/images/certificates/ruo.jpg)
GTX48644
ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse, Rat, Xenopus
Overview
- SupplierGeneTex
- Product NamePDCD4 (phospho Ser457) antibody [2E10.C12]
- Delivery Days Customer10
- ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID2E10.C12
- Concentration1 mg/ml
- HostMouse
- IsotypeIgG
- Modification TypePhosphorylated
- Scientific DescriptionProgrammed cell death 4 (Pdcd4) is a novel tumor supressor. Pdcd4 directly inhibits the helicase activity of eukaryotic translation initiation factor 4A (eIF4A), a component of the translation initiation complex. Pdcd4 also suppresses the transactivation of activator protein-1 (AP-1)-responsive promoters by c-Jun. Pdcd4 contains two Akt phosphoryl-ation sites, one at Ser67 and the other at Ser457. The phosphorylation of Pdcd4 by Akt causes nuclear translocation of Pdcd4 and a significant decrease in the ability of Pdcd4 to interfere with the transactivation of AP-1-responsive promoters by c-Jun.
- ReactivityHuman, Mouse, Rat, Xenopus
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203