PF 477736 [952021-60-2]
HY-10032
Overview
- SupplierMedChem Express
- Product NamePF 477736 [952021-60-2]
- Delivery Days Customer10
- CAS Number952021-60-2
- CertificationResearch Use Only
- Estimated Purity98%
- Molecular FormulaC22H25N7O2
- Molecular Weight419.48
- Scientific DescriptionPF 477736 (PF 00477736) is a potent, selective and ATP-competitive inhibitor of Chk1, with a Ki of 0.49 nM, it is also a Chk2 inhibitor, with a Ki of 47 nM. PF 477736 shows VEGFR2, Fms, Yes, Aurora-A, FGFR3, Flt3, and Ret (IC50=8 (Ki), 10, 14, 23, 23, 25, and 39 nM, respectively). PF 477736 can enhance Gemcitabine antitumor activity in vitro and in vivo.
- SMILESO=C([C@@H](C1CCCCC1)N)NC2=CC3=C(C(C=NNC4=O)=C(N3)C5=CN(N=C5)C)C4=C2
- Storage InstructionSee Manual
- UNSPSC12352200