PLEKHG6 Polyclonal Antibody
RD75990A
ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse
TargetPLEKHG6
Overview
- SupplierReddot Biotech
- Product NamePLEKHG6 Polyclonal Antibody
- Delivery Days Customer5
- ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.4 mg/ml
- ConjugateUnconjugated
- Gene ID55200
- Target namePLEKHG6
- Target descriptionpleckstrin homology and RhoGEF domain containing G6
- Target synonymsMyoGEF; myosin II interacting GEF; myosin interacting guanine nucleotide exchange factor; PH domain-containing family G member 6; pleckstrin homology domain containing, family G (with RhoGef domain) member 6; pleckstrin homology domain-containing family G member 6
- HostRabbit
- IsotypeIgG
- Scientific DescriptionPLEKHG6 functions as a guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. It activates RHOG but not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving MyoGEF, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis.
- ReactivityHuman, Mouse
- Storage Instruction-20°C
- UNSPSC12352203