PROTAC Bcl2 degrader-1 [2378801-85-3]
HY-125876
CAS Number2378801-85-3
Product group Chemicals
Estimated Purity98.54%
Molecular Weight941.84
Overview
- SupplierMedChem Express
- Product NamePROTAC Bcl2 degrader-1 [2378801-85-3]
- Delivery Days Customer10
- CAS Number2378801-85-3
- Estimated Purity98.54%
- Molecular FormulaC45H45BrN6O10S
- Molecular Weight941.84
- Scientific DescriptionPROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC based on Cereblon ligand, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 microM; DC50, 3.0 microM) and Mcl-1 (IC50, 11.81 microM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1.
- SMILESO=C(NCCOCCOCCNC1=CC=CC(C(N2C3CCC(NC3=O)=O)=O)=C1C2=O)CCCCC(NCCN4C(C5=C6C(C4=O)=CC=C(C6=CC=C5)SC7=CC=C(C=C7)Br)=O)=O
- Storage Instruction-20°C,-80°C
- UNSPSC12352200