GTX83773 FACS Image
PSMD10 antibody [3F6] - Overexpression Validated
GTX83773
Overview
- SupplierGeneTex
- Product NamePSMD10 antibody [3F6] - Overexpression Validated
- Delivery Days Customer10
- ApplicationsFlow Cytometry, Western Blot
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID3F6
- Concentration1 mg/ml
- HostMouse
- IsotypeIgG
- Scientific DescriptionActs as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and TP53/p53. Overexpression is leading to phosphorylation of RB1 and proteosomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to TP53/p53 and the mono- and polyubiquitination of TP53/p53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export.
- ReactivityHuman
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203