GTX104015 IP Image
Pyruvate Dehydrogenase E1 alpha antibody
GTX104015
Product group Antibodies
Overview
- SupplierGeneTex
- Product NamePyruvate Dehydrogenase E1 alpha antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1.67 mg/ml
- IsotypeIgG
- Scientific DescriptionThe pyruvate dehydrogenase complex is a nuclear-encoded mitochondrial matrix multienzyme complex that provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle by catalyzing the irreversible conversion of pyruvate into acetyl-CoA. The PDH complex is composed of multiple copies of 3 enzymes: E1 (PDHA1); dihydrolipoyl transacetylase (DLAT; MIM 608770) (E2; EC 2.3.1.12); and dihydrolipoyl dehydrogenase (DLD; MIM 238331) (E3; EC 1.8.1.4). The E1 enzyme is a heterotetramer of 2 alpha and 2 beta subunits. The E1-alpha subunit contains the E1 active site and plays a key role in the function of the PDH complex (Brown et al., 1994 [PubMed 7853374]).[supplied by OMIM]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Critical Role of the Neonatal Fc Receptor (FcRn) in the Pathogenic Action of Antimitochondrial Autoantibodies Synergizing with Anti-desmoglein Autoantibodies in Pemphigus Vulgaris. Chen Y et al., 2015 Sep 25, J Biol ChemRead more
- Protein kinase B (PKB/AKT1) formed signaling complexes with mitochondrial proteins and prevented glycolytic energy dysfunction in cultured cardiomyocytes during ischemia-reperfusion injury. Deng W et al., 2014 May, EndocrinologyRead more
- Selective knockdown of hexokinase 2 in rods leads to age-related photoreceptor degeneration and retinal metabolic remodeling. Zhang R et al., 2020 Oct 20, Cell Death DisRead more
- Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization. Chao LC et al., 2012 Dec, J Lipid ResRead more
- Thiamine mimetics sulbutiamine and benfotiamine as a nutraceutical approach to anticancer therapy. Jonus HC et al., 2020 Jan, Biomed PharmacotherRead more