Rat IL-33 protein
ORB107761
Product group Proteins / Signaling Molecules
Overview
- SupplierBiorbyt
- Product NameRat IL-33 protein
- Delivery Days Customer16
- Applications SupplierHPLC, SDS-PAGE
- CertificationResearch Use Only
- Estimated Purity>95%
- Scientific DescriptionInterleukin-33 (IL-33), also known as NF-HEV and DVS 27, is a cytokine belonging to the IL-1 superfamily. It is also aproinflammatory protein that may regulate gene transcription and it induces helper T cells, mast cells, eosinophils and basophilsto produce type 2 cytokines. The induction of type 2 cytokines by IL-33 in vivo is believed to induce the severe pathologicalchanges observed in mucosal organs following administration of IL-33. IL-33 is constitutively expressed in smooth muscle andairway epithelia and it binds to a high-affinity receptor family member ST2. In vivo administration of mature IL-33 promotesincreased production of IL-5, IL-13, IgE, and IgA, as well as splenomegaly and inflammatory infiltration of mucosal tissues.Recombinant rat IL-3 contains 156 amino acid residues and it shares 59 % a.a. and 90 % sequence identity with human andmurine IL-33.
- SourceE.coli
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352202